Recently, several problems have been discovered in the investigation of cucumber cultivation in plastic greenhouses of Xiao Huangzhu Zhu Yonglong in Daxing District. In order to increase the vigilance of farmers in the cultivation of cucumbers in plastic greenhouses, timely prevention and control to avoid the occurrence of the above problems, The existing problems and management suggestions are briefly described as follows: Ibrutinib is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK) that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinemia, a form of non-Hodgkin's lymphoma.
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I. Problems in production
1, the phenomenon of flowering in cucumbers appears in summer (Figure 1)
Cucumber flower topping, also known as “flower head†or “top flowerâ€, is a common physiological disease on cucumbers in greenhouses. Its main symptoms are: the internodes near the growth point are shortened; The clusters of flowers that are in the shape of "flower heads" have a great influence on the yield and quality.
The main causes of flower topping phenomenon are: reproductive growth and vegetative growth disorders of plants; root activity decline; phytotoxicity occurs, plant growth is inhibited. The specific reasons are as follows:
(1) The soil is dry, the fertilizer is too much and the root is damaged, or the soil is long and damp and rooting.
(2) medication is irrational. The amount of flower hormones should be appropriate and the time of use should not be too early. Scientific medicine should be used to prevent disease and prevent the occurrence of injury.
2, premature aging of plants, some death phenomenon (Figure 2, Figure 3)
Due to the large amount of water required during the fruiting period of cucumbers, cucumbers are often watered during the prosperous period in order to reduce the temperature in the shed. However, due to poor water control and poor cultivating, it is very easy to cause the roots of cucumbers to be stunted due to the roots of cucumber pods. Addition of root-knot nematode harm resulted in weaker overall growth of cucumber plants, smaller leaves, about 10% reduction in leaf area, yellowing of leaves, shortening of internodes from 10-15cm to 5-6cm, severe damage by root knot nematodes There is a phenomenon of death.
Second, management advice
1. Prevention measures and prevention measures for flower topping prevention and control measures: Prevention measures: (1) Reasonable application of fertilizer and water. Greenhouse cucumber fertilization, to grasp a small amount, multiple times, Shi Liu, the application of organic fertilizer must be fully decomposed, evenly topdressing, to prevent improper rooting due to improper fertilization; timely and appropriate amount of water, to avoid flooding caused by flooding root; timely loose soil, Increase soil temperature, promote root development, and produce new roots. (2) Remedial measures. Plants with flowering toppings have appeared, female flowers have been removed in appropriate amounts and sprayed with potassium dihydrogen phosphate 300 times; when watering of rooted flowers occurs, watering is done in time so that the water holding capacity of the soil reaches 22%, and the relative humidity of the air reaches 65%, irrigated with water. Can also be used 5mg/L aqueous solution of naphthalene acetic acid and love more than 3000 times mixed root irrigation, stimulate new roots as soon as possible. Remove all the size of the seeds can be seen on the plant, reduce the burden of plant squash. At the same time, the plants are sprayed with a regulator that can quickly promote the growth of stems and leaves, such as natural cloudhead (Yunda 120), love more, harvest No. 1, etc., to promote the growth of stems and leaves; follow up with available nitrogen fertilizer (ammonium nitrate), generally 7 to 10 days can be basically restored, then gradually transferred to normal management.
2. Prevention and treatment of premature aging of plant and dead cockroaches Cucumber production during summer and over-summer production in plastic greenhouses should be promoted in the middle and later stages to control the amount of irrigation, timely cultivating promote root growth, and increasing the spraying efficiency of leaves to promote the growth of stems and leaves, and timely removal. Commodity ripe melon (should not be large enough) to control too much burden of quails, at the same time, timely control of root knot nematodes in cultivator.
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, and marginal zone lymphoma.
We produce a series of complete intermediates for Ibrutinib, intermediate I (CAS No. 330786-24-8) and intermediate II (CAS No. 143900-44-1) etc.
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