The modern female childbearing age pushes and pushes again. It is impossible to fulfill the child's natural law. What should I do? Helping modern technology, assisted reproductive technology has become a magic weapon. Recently, however, a recent study by Cambridge University researchers published in the journal Nature Communications pointed out that the aging of the uterus with maternal age is the root cause of pregnancy-related complications. This tells us that for most women, frozen eggs may not achieve the results they want. Even if there are good quality eggs, the old body is hard to suffer. After 40 years of age, the risk of pregnancy abortion, stillbirth, and premature birth is significantly increased. In the interview, Dr. Ge Mingxiao, deputy director of the Reproductive Medicine Center of the Third Affiliated Hospital of Sun Yat-sen University, repeatedly stressed that assisted reproductive technologies including “test tube baby†cannot cross the red line of natural law. “Face to face aging eggs†, ovaries, medicine is also limited." "Old" oocytes, "abnormal" placenta, who is in the end? As we all know, 25-30 years old is the most suitable age for women to conceive and give birth. Early studies have shown that after the age of 35, the rate of stillbirth in women during pregnancy will double, and the rate of stillbirth in women who are pregnant around 45 is 3-4 times the age of optimal delivery. Why are women at 35 years old at such a high risk of pregnancy? In the past, it was generally believed that with age, the probability of oocyte chromosome segregation errors increased almost exponentially, so older women were prone to produce karyotyped eggs, leading to spontaneous abortion in pre-pregnancy. Reduced the success rate of women's pregnancy. Therefore, the topic of freezing eggs in recent years is also hot. Like the 35-year-old Zhang Yuning, there are not a few people who think about frozen eggs. Especially the female stars are more honest than one, such as Xu Jinglei, such as Lin Zhiling, after freezing eggs, Xu Jinglei often recommends this technology to her girlfriends. She has many years of age. A similar girlfriend, when someone wants a child, finds it difficult to conceive. Her advice is that as long as you have economic strength, you should do frozen eggs. However, researchers have discovered different phenomena in the past. The latest research published in the journal Nature Communications was conducted by researchers from the University of Cambridge in collaboration with Dr. Myriam Hemberger of the Babraham Institute. Dr. Hemberger has long been committed to the study of embryonic development. In Dr. Hemberger's view, although chromosome segregation errors in oocytes can explain the spontaneous abortion in older women in early pregnancy, this does not explain a series of complications in the second trimester of pregnancy, such as perinatal death, stillbirth, and premature birth. , low birth weight and so on. Because most of the embryos with these complications have no chromosomal abnormalities. More importantly, early studies have shown that these pregnancy complications are often accompanied by abnormal placental development. Therefore, Dr. Hemberger suspected that abnormal placental development may be the main cause of pregnancy complications associated with maternal age. To test this hypothesis, Dr. Hemberger selected fertile old female mice and young female mice to conduct experiments to analyze the embryos and placental development of these mice after pregnancy. She found through experiments that age-related pregnancy complications are not caused by "old" oocytes, but by "abnormal" placenta. Overall, Dr. Hemberger's study showed that with age, aging endometrial epithelial cells are gradually less sensitive to hormones and lead to abnormal placental development, which is the main cause of age-related pregnancy complications. the reason. Assisted reproduction is not at the limit "Of course, the above is only a study, it is not conclusive, and it needs further confirmation." Ge Mingxiao said that at this stage we can be clear that age is closely related to fertility, and with the increase of age, fertility gradually declines. We used to say that "people will win the day", but people still can't resist the power of nature. Dr. Ge quoted relevant authoritative statistics as saying that the total spontaneous abortion rate of women of childbearing age is about 10%-15%, the abortion rate can be as high as 20% at the age of 35, and the abortion rate is more than 50% when the age is 44. This data is very height of. As pregnant women increase their age, the chance of chromosomal abnormalities in the fetus increases. Under the age of 35, about 800-1000 pregnancies, there is a congenital stupidity, 35-40 years old, every 500 times of pregnancy, there is a congenital stupid, After the age of 40, every 200 pregnancies, there is an abnormal fetal. Ge Mingxiao said, "More intuitively, usually, the natural fertility has come to an end in the first decade of menopause. The average age of menopause in Chinese women is 49.5 years old." "The success rate and age of IVF are also significantly related." In our clinical situation, 25 to 35 years old is the period with the highest success rate, especially after 35 years old, the success rate is gradually decreasing. After 40 years old, it is 20% or less. So IVF is just a hope, but "usually women are over 45 years old and we euphemistically recommend giving up." Why do you say that? "We did IVF surgery and found that the success rate was significantly lower after the age of 40. The 43-44 years old basically fell straight down. After 45 years old, the success rate is close to the bottom line. "Working for so many years, I was successful in receiving patients. The oldest childbirth is 44 years old, and a 46-year-old has been successfully conceived but has had multiple abortions. †"So, we can't challenge the birth age limit. Assisted reproductive technology is not to challenge the so-called fertility limit, but to treat infertility and help these couples with infertility to conceive." Ge Mingxiao further introduced, such as in vitro Fertilization-embryo transfer indications (commonly known as the first generation of IVF) mainly solve female infertility in tubal occlusion, such as tuberculosis patients, severe pelvic adhesions, tubal blockage, fallopian tube resection and other infertility; intracytoplasmic spermatozoa Microinjection indications (commonly known as the second generation of IVF) solve the problem of infertility mainly caused by male infertility, such as severe and weak, may be treated by Chinese and Western medicine, but still only a few live Articles, only a few, a dozen spermatozoa are seen under high magnification, there is no way to naturally conceive, natural pregnancy usually requires at least 2 million active spermatozoa; preimplantation genetic diagnosis (PGD, commonly known as third generation test tube Infant) refers to the analysis of genetic material of the embryo prior to embryo transfer, diagnosis of abnormalities, screening of healthy embryo transfer, prevention of genetic diseases Methods of transmission, such as thalassemia genetic diseases, can be avoided by third-generation techniques. In addition, Ge Mingxiao emphasized that there are strict limits on frozen eggs in China. Today's “frozen eggs†belong to the category of assisted reproduction. Usually, frozen eggs are considered for medical corrections and approval by the ethics committee. The requirement for unmarried female eggs to be frozen is not currently accepted. What can I do before I meet Ruyi Langjun? Since age is a hurdle that cannot be crossed, freezing eggs is not a matter of expediency. What can women's friends who still have a fertility wish before they have met Ruyi Lang and have not given birth? Ge Mingxiao gave three suggestions. First of all, you must take good contraceptive measures to prevent secondary infertility before you plan to become pregnant. Accidental pregnancy, regardless of abortion or medical abortion, whether it is painless or other, as long as abortion has injury, "Do not listen to some advertising." Dr. Ge stressed that abortion will lead to a series of fertility problems, such as people flow The intrauterine adhesion caused by surgery is about 10%-20%, and intrauterine adhesion is a common cause of infertility. Infertility caused by pelvic inflammation is also increasing year by year. For contraceptive methods, Dr. Ge recommends short-acting oral contraceptives, condoms, etc., especially emergency contraceptives are not recommended. Second, the lifestyle must be healthy. Unhealthy lifestyles, including staying up late, have a major impact on pregnancy. This is an old-fashioned question. "But we have seen that many people are not in place. While doing test-tube baby, they work day and night and work hard." Dr. Ge said that long-term staying up late causes the clock to become disordered, and then the endocrine metabolism. Disorder, long-term will affect fertility. We must advocate for an active and healthy lifestyle, regular work routine, healthy diet, reasonable exercise, and good emotional spirit. Dr. Ge said that life is not only healthy but also psychological. Stress and poor mental state can also cause fertility decline. Third, regular medical examinations. Every six months to one year to do an examination, the inspection items include routine gynecological examination (cervix, vaginal discharge, etc.), like vaginal discharge to see if there is inflammation; ultrasound examination, B-ultrasound can be found ovarian cysts, uterine fibroids, endometriosis And other organic diseases, while B-ultrasound can also check the ovarian reserve function. Sex hormones and thyroid function tests are also important. In recent years, thyroid function tests have gradually gained attention, which is one of the important indicators that affect pregnancy and affect fetal health. If B-ultrasound and sex hormone tests find abnormal ovarian reserve function, Dr. Ge Mingxiao recommends that you can do anti-Mullerian hormone (AMH) examination. In recent years, many domestic centers have also carried out the inspection of this hormone. AMH combined with basic hormones and ultrasound to measure the number of ovarian sinus follicles, more accurately assess ovarian reserve function. (Southern Daily News) FOSHAN PHARMA CO., LTD. , https://www.pharmainjection.com