Release date: 2017-07-25 With the support of the 973 program, the project "Regulatory Network Research and Transformation Application of Cell Destiny in Different Stages of Neural Differentiation" has made important progress, and discovered the key molecules and mechanisms of action of cells to sense and respond to changes in the external environment. The organism is always in a changing environment inside and outside the cell, such as temperature, pH inside and outside the cell and osmotic pressure. All organisms need to feel these changing internal and external environments and respond accordingly to maintain the normal physiological functions of the cells. However, it is not clear how cells respond to environmental changes. Professor Zhang Xiaoqing from Tongji University discovered a transcription factor Smad5 that can sense changes in temperature, extracellular pH and osmotic pressure. When the extracellular environment changes, Smad5 can quickly capture the subtle changes in intracellular pH and regulate it through nucleoplasmic shuttle. Intracellular energy homeostasis. Knocking out Smad5 causes disturbances in intracellular energy homeostasis and interferes with normal developmental processes. This is the first time to discover how cells respond to changes in the external environment, maintain the mechanism of intracellular metabolic homeostasis, deepen the understanding of the establishment and maintenance of intracellular pH and metabolic homeostasis, and lay the foundation for drug development, cell transplantation and treatment. The results of the study were published in the July 2017 issue of Cell Research. Source: Ministry of Science and Technology Pesticide And Veterinary medicine material Tetracycline hydrochloride and other tetracyclines are broad-spectrum antibiotics, which have inhibitory effects on most gram-positive and negative bacteria, bactericidal effects at high concentrations, and can inhibit rickettsia and chlamydia trachomatis, etc., and are more effective on gram-negative bacteria. it is good. Its mechanism of action is mainly to prevent the combination of aminoacyl and ribosome ribosomes, prevent the growth of peptide chains and the synthesis of proteins, thereby inhibiting the growth of bacteria, and also has bactericidal effect at high concentrations. There is cross-resistance between this product and oxytetracycline. Clinically, it is mainly used for bacillary dysentery, trachoma, whooping cough, pneumonia, suppurative meningitis, skin infection and otitis media. Pesticide And Veterinary Medicine Material,Levamisole Powder,Doxycycline Hcl,Tetracycline Hydrochloride SHAANXI HAIBO BIOTECHNOLOGY CO., LTD , https://www.rozenbio.com