Scientists install "brakes" in cancer cells to force the cancer cells to grow wild!

Scientists install "brakes" in cancer cells to force the cancer cells to grow wild!

May 31, 2017 Source: Cancer 123

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Although cancer is an extremely complex disease, its definition is quite simple, that is, the growth of abnormal and uncontrollable cells. Researchers at the University of Rochester's RNA Biology Center have identified a new technology that slows the growth of cancer cells, which is suitable for all types of cancer. The results of the report were published in the journal Science today, and the study was funded by the National Institutes of Health. Although there is still a long way to go, this technology will undoubtedly point the way for future treatment.

Cancer: cell cycle error

All cells have a cell cycle and are a series of ordered cell growth and division. In cancer, the cell cycle is disordered, cell division does not stop or invade surrounding tissues. In this study, the researchers discovered a protein called Tudor-SN protein that plays an important role in both the cell cycle preparation phase and the division phase. When scientists eliminate this protein from cells, cells take longer to prepare for division. Deletion of Tudor-SN can slow the cell cycle.

"We found that the amount of Tudor-SN protein in cancer cells is staggering compared to healthy cells, so if it is based on this property, it may be expected to slow the growth of cancer cells," the researchers said.

Install brakes in cancer cells

The researchers found that Tudor-SN proteins affect the cell cycle by modulating small RNAs, and if Tudor-SN proteins are removed, small RNA levels increase. Promoting the level of small-molecule ribonucleic acid is equivalent to installing a brake in the gene that promotes tumor growth, which effectively controls the tumor to grow.

The researchers said: "Because cancer cells have the wrong cell cycle, using this feature to fight cancer is a promising treatment."

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