Honey pill is a major and clinically widely used dosage form of zui in traditional Chinese medicine pills. It has occupied an important position since ancient times. Many chronic diseases, cancer patients, Zui fit. Because honey contains a lot of nutrients such as sugar, organic acids and vitamins, it has the functions of nourishing, antitussive, slowing down, moistening and detoxifying, and contains a large amount of reducing sugar, which can prevent the degeneration of oxidative components of traditional Chinese medicine. And the refining honey has strong adhesion. After mixing with the powder, the pill is not easy to be hardened, and has a large plasticity. The prepared pellets are smooth, moist, slow to disintegrate, and durable in medicine, and are a good binder. However, the selection and refining of honey in the production and processing of honey pellets can directly affect the formation, moisture absorption, mildew or hardness of the pellets, failing to meet the requirements of the finished hygiene index and affecting the efficacy of the drug. Now summarize his experience as follows.
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1. The choice of honey and the quality of honey are different depending on the type of honey plant. The quality of the honey is different. In order to ensure the softness of the honey pill, the storage of the honey pill is thick or liquid with a milky white or light yellow paste. The aroma is strong, the taste is pure and sweet, not sour, clean and free from impurities. It is translucent when fresh, and the crystals of sugar are deposited for a long time, and the specific gravity is 1.41.45 at 15 °C. If the syrupy liquid or the bottom layer has agglomerates, the thick color is darker, the taste is sour, the bitter is numb, and the human medicine should not be used.
Honey often contains water and impurities. It must be refined and filtered before application to kill microorganisms, reduce water content and enhance adhesion. The texture of the fine powder of traditional Chinese medicine is different from the season of processing pills. When heating honey, the heating time, temperature, color of honey and so on should be strictly controlled. There are three kinds of sweet honey, honey, and honey. If the refining method is improper, it will cause wrinkles, mold, dryness and other undesirable phenomena during the storage period of the finished product. In the practice, the author realized that in order to ensure that the honey pill is bright, moist, soft, moderately soft and soft, when the refining honey meets the requirements of the prescription drugs, when the honey is about to be released, the cold water is added twice in succession, and each time it is added to be boiled. When you add it again. That is to say, the amount of water added is about 15m1 per kilogram. The sampled honey can reduce the adhesion and sticking of the drug and the tool, and can also avoid the loss of the drug and reduce the amount of the lubricant.
2. The degree of honey used in the preparation of honey in the preparation of honey pills, the temperature of the Chinese medicine fine powder mixed with honey is the key to the quality of the finished product and the difficulty of operation. It should be based on the nature of the prescription drug. Generally, the powder can be used as hot honey. If the formula contains volatile oil, colloid, resin and strong adhesive ingredients, it is advisable to use cold honey. The amount of honey used is closely related to the nature of the drug and the climate. Generally refers to the rhizome, the quality of the fine powder medicine with a honey amount of 1:1, the fine powder of flowers, fibers, minerals, and old honey, the amount of honey used is: about 1.5, used in summer The amount of honey is generally small, and the amount of honey used in winter is high. Otherwise, the honey pill is difficult to form, and the finished product is hard and mildewed.
3. Elimination and Prevention of Microbial Contamination The Chinese Pharmacopoeia has already made a limit on the bacterial index of Chinese medicinal materials. However, the raw material index of traditional Chinese medicines often exceeds the standard. Honey absorbs moisture and is easily contaminated by microorganisms in the operation. It must survive and reproduce. Effective measures must be taken during operation.
3.1 Carefully select the original medicinal materials, remove the non-medicinal parts, dry, and keep the packets in reserve to avoid pollution.
3.2 After the medicinal material is pulverized into fine powder, it is dried and sterilized.
3.3 In the operation of medicine, purlin and pelleting, 75% alcohol disinfection or ultraviolet sterilization, the operator Zui is good to process under aseptic conditions.
3.4 After the honey pill is made, it must be packaged immediately, sealed with wax paper or wax shell. The packaging material should also be sterilized to ensure the quality of the finished product, improve the hygiene requirements of the pill, and meet the national Pharmacopoeia standards. Make the finished honey pill safe and effective.
4. Wide range of clinical applications. Honey pill has a long-lasting average of more than 1,000 applications per year. Some chronic diseases, such as chronic bronchitis, tuberculosis, and stomach diseases, are common in cancer; cancer, such as stomach cancer, liver cancer, and uterine cancer, are in the process of treatment. The time taken for taking the decoction is long and the patient is difficult to accept. The doctor uses the syndrome differentiation method to make the honey pill, which is convenient to take, and has long-lasting effect, and plays the characteristics of the pill. In particular, it reflects the importance of the production and processing of honey pill.
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