"Nature" published the latest cancer research results revealing the mechanism of tissue loss in patients with pancreatic cancer

"Nature" published the latest cancer research results revealing the mechanism of tissue loss in patients with pancreatic cancer

June 22, 2018 Source: Science and Technology Daily

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The British "Nature" magazine published a new cancer research on the 20th: American scientists unveiled the mechanism of tissue consumption in patients with pancreatic cancer. Studies have shown that changes in pancreatic exocrine function are likely to be the cause of adipose tissue and skeletal muscle consumption in patients with pancreatic cancer.

Cancer is hidden under the "line of sight" of the immune system. When cancer cells appear, the body's natural tumor monitoring program should be able to detect and attack them, and only when these defense systems fail, can cancer thrive. Previous studies by scientists have found that changes in cellular metabolism are symptoms of various forms of cancer. The peripheral tissue consumption is particularly closely related to pancreatic cancer. This metabolic syndrome reduces the quality of life and is also thought to reduce the survival rate of cancer patients. Organizational consumption has multiple causes, but unfortunately, it has been difficult to determine the exact underlying mechanisms.

This time, Massachusetts Institute of Technology scientist Matthew van der Heiden, Dana Farber Cancer Institute scientist Brian Volbin and their colleagues, using mouse pancreatic cancer model found that fat tissue and bone Muscle depletion occurs early in the development of the disease, and it is the growth of pancreatic tumors that is caused by peripheral tissues, rather than tumor growth at other sites.

At the same time, the research team also found that the decline of pancreatic exocrine function promotes the loss of adipose tissue. Supplementation of pancreatic enzyme can alleviate peripheral tissue consumption, but does not improve the survival rate of mice.

In cancer, pancreatic cancer is a malignant tumor of the digestive tract that is highly malignant and difficult to diagnose and treat. Its morbidity and mortality have been rising significantly, because the early diagnosis rate of pancreatic cancer is not high, the operative mortality rate is high, and the cure rate is also low. Moreover, the cause of pancreatic cancer has not been fully understood so far. The researchers said that 65% of the 782 patients with pancreatic cancer had symptoms of skeletal muscle consumption at the time of diagnosis. However, adipose tissue and skeletal muscle consumption were not associated with a reduction in patient survival. Therefore, the peripheral tissue consumption of pancreatic cancer in the early stage may be the early warning signal of the disease, but it may not be related to the short survival period. (Reporter Zhang Mengran)

Editor-in-chief

"The king of cancer" makes people smell discolored. This is mainly because the early diagnosis rate of pancreatic cancer is not high, and the operative mortality rate is high, and the cure rate is low. The medical community has been trying to conduct in-depth research on molecular typing of different characteristics of pancreatic cancer population to explore the mechanism of the occurrence and development of this disease, so as to find new intervention targets for clinical. There are still many unknown humans around pancreatic cancer, and its exploration is bound to be long, but all efforts in this field will benefit more patients.

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