Raw Powder Milrinone CAS 78415-72-2 Active Pharmaceutical Intermediate

Model NO.: 78415-72-2
Delivery Time: 5-10 Days
Payment Terms: T/T, Western Union, Moneygram, Bitcoin
Minimum Order: 10g
Storage: Shading, Confined Preservation
Appearance: White Powder
MW: 211.22
Mf: C12h9n3o
Policy: Re-Shipping Policy
Specifications: 99% Purity
Supply Ability: 5000kg Per Month
Trademark: JZY
Transport Package: Disguised Package
Specification: White powder
Origin: China
Model NO.: 78415-72-2
Delivery Time: 5-10 Days
Payment Terms: T/T, Western Union, Moneygram, Bitcoin
Minimum Order: 10g
Storage: Shading, Confined Preservation
Appearance: White Powder
MW: 211.22
Mf: C12h9n3o
Policy: Re-Shipping Policy
Specifications: 99% Purity
Supply Ability: 5000kg Per Month
Trademark: JZY
Transport Package: Disguised Package
Specification: White powder
Origin: China

Basic info:

Product Name                                                                        Milrinone
Synonym
1,6-DIHYDRO-2-METHYL-6-OXO-3,4-BIPYRIDINE-5-CARBONITRILE;1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTINONITRILE;4'-bipyridine)-5-carbonitrile,1,6-dihydro-2-methyl-6-oxo-(;win47203;MILRINONE;Milirinone;MilrinoneUsDmf;2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBONITRILE
 
CAS No
78415-72-2
 
MF
C12H9N3O
 
MW
211.22
 
EINECS
278-903-6
 
Appearance
White powder
 
Melting Point
>3000°C
 
Purity
99%
 
Grade
Pharma Grade
 
Usage
Antidepressant, 5HT reuptake inhibitor .For digitalis, diuretics, vasodilators ineffective or ineffective treatment of various causes of acute and chronic intractable congestive heart failure .
 
Usage
Bronchodilator.Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic
 



Description

Milrinone is a medication used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance. Milrinone also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. 

Overall, milrinone supports ventricular functioning of the heart by decreasing the degradation of cAMP and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate. In the short term milrinone has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival.

Mechanism of action

Milrinone is a phosphodiesterase-3 inhibitor.This drug inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP. With increased cAMP levels there is an increase in the activation of PKA. This PKA will phosphorylate many components of the cardiomyocyte such as calcium channels and components of the myofilaments. Phosphorylation of calcium channels permits an increase in calcium influx into the cell.

This increase in calcium influx results in increased contractility. PKA also phosphorylates potassium channels promoting their action. Potassium channels are responsible for repolarization of the cardiomyocytes therefore increasing the rate at which cells can depolarize and generate contraction. PKA also phosphorylates components on myofilaments allowing actin and myosin to interact more easily and thus increasing contractility and the inotropic state of the heart. Milrinone allows stimulation of cardiac function independently of β-adrenergic receptors which appear to be down-regulated in those with heart failure.

 

Raw Powder Milrinone CAS 78415-72-2 Active Pharmaceutical Intermediate


Raw Powder Milrinone CAS 78415-72-2 Active Pharmaceutical Intermediate


Payment Information:
 
Price negotiable according to how many do you need
Payment Term TT/West Union /Bitcoin/ Money Gram
Delivery Time normally 5-10 days by express
Shipping way Express(EMS,DHL,TNT,FedEX;HKDHL;EUB) Door to Door
Transport by air for large quantity.
Shipping Time Most countries can arrived within 3-10 days  


Our Advantages:
 
1. High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
 
2. Fast and safe delivery:
 
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
 
3. We have clients throughout the world:
 
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 
We are the manufacturer of all kinds of hormone powders. We focus on providing customers with high quality products, competitive price, best service and timely delivery. Price: Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference. Payment methods: Western Union, MoneyGram We will supply the receiver's information or the bank account information for payment use. Shipping items: Shipping items will be delivered by international express like EMS, TNT, UPS, FedEx or DHL after receiving received. Every item will be shipped out in 2-3 working days after the payment is done. The product usually arrives in 1-4 days based on the different destination, and online track is provided. Please kindly supply the shipping address, contact and tel number for successful shipment. We are 100% confident of my shipment method, None of our previous packages has ever had any delivery issues.


 

Basic info:

Product Name                                                                        Milrinone
Synonym
1,6-DIHYDRO-2-METHYL-6-OXO-3,4-BIPYRIDINE-5-CARBONITRILE;1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTINONITRILE;4'-bipyridine)-5-carbonitrile,1,6-dihydro-2-methyl-6-oxo-(;win47203;MILRINONE;Milirinone;MilrinoneUsDmf;2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBONITRILE
 
CAS No
78415-72-2
 
MF
C12H9N3O
 
MW
211.22
 
EINECS
278-903-6
 
Appearance
White powder
 
Melting Point
>3000°C
 
Purity
99%
 
Grade
Pharma Grade
 
Usage
Antidepressant, 5HT reuptake inhibitor .For digitalis, diuretics, vasodilators ineffective or ineffective treatment of various causes of acute and chronic intractable congestive heart failure .
 
Usage
Bronchodilator.Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic
 



Description

Milrinone is a medication used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance. Milrinone also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. 

Overall, milrinone supports ventricular functioning of the heart by decreasing the degradation of cAMP and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate. In the short term milrinone has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival.

Mechanism of action

Milrinone is a phosphodiesterase-3 inhibitor.This drug inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP. With increased cAMP levels there is an increase in the activation of PKA. This PKA will phosphorylate many components of the cardiomyocyte such as calcium channels and components of the myofilaments. Phosphorylation of calcium channels permits an increase in calcium influx into the cell.

This increase in calcium influx results in increased contractility. PKA also phosphorylates potassium channels promoting their action. Potassium channels are responsible for repolarization of the cardiomyocytes therefore increasing the rate at which cells can depolarize and generate contraction. PKA also phosphorylates components on myofilaments allowing actin and myosin to interact more easily and thus increasing contractility and the inotropic state of the heart. Milrinone allows stimulation of cardiac function independently of β-adrenergic receptors which appear to be down-regulated in those with heart failure.

 

Raw Powder Milrinone CAS 78415-72-2 Active Pharmaceutical Intermediate


Raw Powder Milrinone CAS 78415-72-2 Active Pharmaceutical Intermediate


Payment Information:
 
Price negotiable according to how many do you need
Payment Term TT/West Union /Bitcoin/ Money Gram
Delivery Time normally 5-10 days by express
Shipping way Express(EMS,DHL,TNT,FedEX;HKDHL;EUB) Door to Door
Transport by air for large quantity.
Shipping Time Most countries can arrived within 3-10 days  


Our Advantages:
 
1. High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
 
2. Fast and safe delivery:
 
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
 
3. We have clients throughout the world:
 
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 
We are the manufacturer of all kinds of hormone powders. We focus on providing customers with high quality products, competitive price, best service and timely delivery. Price: Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference. Payment methods: Western Union, MoneyGram We will supply the receiver's information or the bank account information for payment use. Shipping items: Shipping items will be delivered by international express like EMS, TNT, UPS, FedEx or DHL after receiving received. Every item will be shipped out in 2-3 working days after the payment is done. The product usually arrives in 1-4 days based on the different destination, and online track is provided. Please kindly supply the shipping address, contact and tel number for successful shipment. We are 100% confident of my shipment method, None of our previous packages has ever had any delivery issues.


 

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