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Transgenic cattle: eat grass, squeeze out medicine
Also grazing, cows are no longer pure milk, but a variety of drugs. This is not a delusion of “painting cakes and filling up hungerâ€. Scientists have already experimented successfully. Regrettably, among the thousands of cows that they have worked so hard to develop, they can find out. Therefore, how to obtain higher accuracy has become a matter for them. "Switching" Controls Gene Growth Environment Let's take a look at how milk turns into drugs. The virus was extracted and analyzed which genes were synthesizing its outer shell. After locking the gene, it was implanted into a cell and the cell eventually grew into a transgenic cow. Note that before the gene was implanted in the cell, it was fitted with a biological component that acts like a steering wheel and directs the virus gene to grow only in the breast. This method ensures that cattle do not cause harm. When a cow grows milk, the milk is purified and the virus vaccine is obtained. A cow meets the demand of interferon in the country Nowadays, the level of medical protein produced by the animal mammary gland in the world has reached 3-5 g/L, that is, a GM cow can produce 25-50 kg of medical protein a year if it is interfered with by production. Such as the use of small doses of the product, a cow's output can meet the needs of all of China. “Even for highly used products such as serum albumin, once a transgenic cow has been developed, the performance of target products such as the production of medical protein by genetically modified cows is heritable, and as long as the breeding can produce tons of products Professor Chen Yongfu, director of the 863 program "Development of breast bioreactors for chicken bursal vaccines and other genes" and professor at China Agricultural University, said, "As a result, animal mammary glands are compared with existing technologies such as E. coli and animal cell culture. The reactor has great advantages and is a top technology.†Success is only one in a thousand but the development of animal mammary gland bioreactors is a complex process that is costly, time consuming, and laborious. Chen Yongfu said: “The bottleneck is the low production efficiency of transgenic animals and the uncertainty of gene expression. Using the traditional method of directly injecting DNA into single cell embryos, the transgenic efficiency of sheep, goats and pigs is 1%, ie, the injection is successful. And transplanting 100 embryos can produce 1 transgenic animal, and the cow's transgene efficiency is even lower, only 0.5%.In transgenic animals, because of the position of gene insertion, only 1 out of 10 transgenic animals can reach the ideal production level. The combination of these two factors makes the yield of useful transgenic animals almost insignificant.†In other words, if you want to produce a qualified transgenic cow, you must inject and transplant 2000 embryos and produce 10 transgenic cattle. One transgenic cow with a yield of 3 to 5/liter. “Bulls are single-child animals. Each cow can only transplant one embryo at a time. In Beijing area, a cow costs 10,000 yuan for a year and uses 2,000 cows as recipients for embryo transfer in terms of funds, labor, and It's not a simple matter of time," said Chen Yongfu. The new platform saves costs by 95% "With the efforts during the '15' plan, we have established a technology platform for the direct expression of foreign genes in the mammary gland. The technology platform first realized the innovation of the vector. Using this new vector, transgenic embryos and Non-transgenic embryos can be distinguished with the naked eye.Therefore, only the true transgenic embryos need to be transplanted during embryo transfer, and 95% of recipient cows can be saved. After producing qualified transgenic animals, the marker genes can be removed without affecting the health of the transgenic animals. And the quality of the product. Through the cloning technology to produce animals, the level of function of the second gene will not weaken." Chen Yongfu said. The greatest contribution of this platform to the road to industrialization in the future lies in the fact that GM technology innovation can increase the efficiency of transgenesis by 30 times. By superimposing these two technologies, only 20-30 cows can be used to achieve the effect of transplanting 2,000 cows.